GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10043228 | 1 | rs62384714 | chr5:115452597 | COMMD10 | chr5:115420727-115628978:+ | 0.46 | 5.65 | 2.8E-8 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs62385074 | 1 | rs62385074 | chr5:169731617 | KCNMB1 | chr5:169805167-169816638:- | 0.21 | 3.7 | 0.000242 | Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) |
| THCA | cis | rs10043228 | 1 | rs62385177 | chr5:115480480 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.89 | 7.35E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs10043228 | 1 | rs62385980 | chr5:115592908 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.7 | 2.09E-8 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs10043228 | 1 | rs62385993 | chr5:115602254 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.7 | 2.09E-8 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs13182402 | 1 | rs62391527 | chr5:125904970 | ALDH7A1 | chr5:125878918-125931082:- | 0.45 | 6.44 | 2.92E-10 | Osteoporosis |
| THCA | cis | rs13182402 | 1 | rs62391531 | chr5:125914726 | ALDH7A1 | chr5:125878918-125931082:- | 0.45 | 6.59 | 1.18E-10 | Osteoporosis |
| THCA | cis | rs62402013 | 1 | rs62402013 | chr6:26915000 | BTN3A2 | chr6:26365398-26378546:+ | 0.16 | 3.9 | 0.00011 | Schizophrenia |
| THCA | cis | rs62402013 | 1 | rs62402013 | chr6:26915000 | HCG11 | chr6:26521934-26527610:+ | -0.21 | -3.97 | 8.4E-5 | Schizophrenia |
| THCA | cis | rs62402013 | 1 | rs62402013 | chr6:26915000 | LOC100270746 | chr6:26987146-26988085:- | -0.26 | -6.17 | 1.43E-9 | Schizophrenia |
| THCA | cis | rs9368849 | 1 | rs62404566 | chr6:35118432 | TCP11 | chr6:35085849-35109187:- | -0.25 | -4.11 | 4.75E-5 | Airway responsiveness in chronic obstructive pulmonary disease |
| THCA | cis | rs12196860 | 1 | rs62404862 | chr6:55943199 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs12196860 | 1 | rs62404863 | chr6:55943202 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs12196860 | 1 | rs62404865 | chr6:55944559 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs12196860 | 1 | rs62404866 | chr6:55956146 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |